Of unknown origins, a virulent and destructive virus destroys the AI upon which humanity relies upon. Systems fail; food production, life support, healthcare, even transport stops working, all within a few months of each other. In the anarchic chaos that follows, 95% of the population dies due to starvation, environmental collapse, violence or disease. Entire systems are rendered down to a primitive state, or suffer total population loss.
Some systems are able to either avoid the worst effects, despite losing all AI enabled systems, but no star systems escapes the disaster unscathed. Most devolve down to levels more akin to post-industrial, with a fraction of their previous population. A period of darkness follows.