Leprosy

Leprosy is a debilitating disease that manifests as a gradual deterioration of the flesh, leading to disfigurement and loss of sensation. A highly visible malady, those afflicted are often shunned by society to prevent contagion.
Resisting the Disease. A creature afflicted with leprosy makes a Constitution Saving Throw against their affliction level at the end of every 7 days after contracting the disease.

• Major Success: The creature's affliction level decreases by 1.
• Success: The creature's affliction level remains the same.
• Failure: The creature's affliction level increases by 1.
• Major Failure: The creature's affliction level increases by 2.

Transmission. After onset, an afflicted creature is contagious, a humanoid that remains in continuous close contact (as determined by the GM) risks exposure. When exposed, the humanoid must make a DC 10 Constitution Saving Throw or be Afflicted 5 with leprosy.

Disease Symptoms

Stage (Affliction Level)	Effects
Cured (<1)	The disease ends.
Onset (1-10)	The creature experiences subtle skin discoloration and mild numbness.
Stage 1 (11-20)	As above, but skin discoloration and lesions become more pronounced. The creature has disadvantage on Strength Checks and Saving Throws. The creature cannot regain hit points, except through magical means.
Stage 2 (21-30)	All effects of prior stage, plus severe nerve and tissue damage leading to physical deformities and oozing wounds. The creature has vulnerability to bludgeoning, piercing, and slashing damage.
Stage 3 (>31)	All effects of prior stage. The creature takes 1d4 necrotic damage each time it attempts to resist the disease.