Malaise

Cryohibernation Metabolic Fatigue (The Malaise)

Diagnostic Criteria:

A. The individual has undergone cryogenic freezing and subsequent thawing.
B. Following emergence from cryogenic freezing, the individual experiences a period of metabolic depression characterized by:
Emotional depression (feeling sad, empty, or hopeless)
Fatigue (physical or mental exhaustion)
Distracted mental processes (impaired concentration, confusion)
Apathy (lack of interest or motivation)
C. The symptoms persist for a duration of:
Minimum: 1 day
Maximum: 4 weeks
D. The symptoms are not better explained by another medical or psychiatric condition. Prevalence and Risk Factors:
Cryohibernation Metabolic Fatigue affects a significant proportion of individuals undergoing cryogenic freezing. Risk factors include:
Number of cryogenic cycles
Duration of cryogenic freezing
Individual adaptability to cryogenic processes
Pre-existing mental health conditions

Clinical Features and Course:

The Malaise typically resolves spontaneously within 1-4 weeks. Symptoms may fluctuate in severity during this period.
Mild cases: Minimal impairment, daily activities unaffected
Moderate cases: Noticeable impairment, daily activities affected
Severe cases: Significant impairment, daily activities severely impacted

Complications:

Increased risk of suicidal ideation (non-lethal)
Impaired cognitive and motor function
Reduced productivity and performance
Treatment and Management: Supportive care: Monitoring, reassurance, and emotional support
Pharmacological interventions (mood stabilizers, stimulants): As needed, under medical supervision
Gradual reintroduction to physical and mental activities

Prognosis:

Full recovery from Cryohibernation Metabolic Fatigue is expected within 1-4 weeks. Recurrence risk increases with subsequent cryogenic cycles. Adaptation to cryogenic processes through repeated exposure may mitigate symptom severity.