Shiver

The first stage of the inquisitive malaise are light but permanent shivers and constantly questioning the nature of things.
For many, that’s the end of it. Since there is no cure for the disease, a patient can live a long, otherwise normal life, tormented by these symptoms. While most will get used to the physical discomfort over a decade or maybe two, the psychological effects of the sickness can often manifest as paranoia, delusions, or rudeness.
Those on the second stage are prone to seek professional help—spiritual, psychological or neurological, depending on their beliefs and priorities—or to end their lives. While a diminution of the shivering and the appearance of marks on the skin were considered the major symptoms of this stage, new research indicates that the need to share or hide their condition is actually part of the evolution of the disease, not a secondary effect of it.
Those who survive the second stage—and the desperate treatments provided by specialists, friends, family and nosy neighbors—enter the third stage, known by loss of energy and a regression to the shivering from stage 1.
It’s a matter of time before they reach the fourth and fifth stage, sometimes considered as the same thing, since the physical symptoms are the same: occasional seizures and full recovery from other symptoms and secondary effects of previous stages.
The perpetual curiosity and worry that capture all the attention of the patient is considered a symptom of the fourth stage, which is the most likely outcome for those who enter the third stage. They will usually starve or die in accidents.
The few that reach stage five, in the past considered as cured—until the seizures continued to happen in all cases—, are capable of functioning in society, the worry and paranoia completely gone and their curiosity manageable. They usually become prominent scientists, researchers or journalists.