Syria, Jordan and Israel.
Fifth Middle East War causes NATO to unravel and the formation of the European Federation.
The 22nd Century saw the start of the true Space Age, with the invention first of the reactionless displacement drive, then the F-Drive. By the end of this century, humanity had made amazing achievements, including the colonisation of the solar system, but had also continued it's warmongering ways, notably in the nuclear Russian Civil War, and the Tau Ceti War.
The 23rd Century sees humanity continue to colonise space. The UEF begins to fracture at its edges, resulting in the Colonial Wars.