Igden, 2nd of Enoray, 2E 1847
This DnD game is set in an entirely homebrew world, albeit one that borrows heavily from Forgotten Realms and other pre-written settings.
The setting focuses on the The Alliance of Galoria, a continent-sized land divided into several large provinces with unique geographical, economic and cultural differences.
Though interplanar connections are weak to the point of near-nonexistence, the Material Plane does fine on its own. Technology in this land has advanced to the point of electricity, steampower, radio and vehicles-- leaving magic a scholarly pursuit in the hands of nobility and academia, very much a mysterious forbidden art to the working-class common man or country rabble.
Think Steampunk Urban Fantasy meets traditional low-magic DnD mystery!