Potiondaze

The magus stumbled, slurring his words of power. He lurched, the small bottle falling from his left hand to the cobbled marble and sandstone road. Make no mistake, he was still dangerous. Perhaps all the more so for the unpredictability this added. He clawed at the throat of his robe as though it was strangling him, before he burst into uncontrolled laughter. His magic discharged, sending streaks of bright opalescent light dancing past the kidnappers. It painted the stone walls of the alley with fluorescent, glowing burns. Sevios heard one of his men yelp in pain, though the sound was cut short by a wet thump. He didn't look back.
"Get them out," he ordered, not taking his eye off the blackrobe. The magus belched, convulsed and vomited a steamy stream of fluid that sizzled as it dribbled to the stones. Sevios knew the chances of escape were narrow. He'd at least take the potiondazed bastard down with him.

5e Rules

Potiondazed.

• A potiondazed creature is considered Poisoned.
• The creature automatically fails any Constitution saving throws.
• The creature has Advantage on Charisma saving throws.
• Saving throws made in response to any magic cast by the potiondazed creature have advantage.

Potiondaze, also known as potion drunk or potion poisoning, is intoxication by alkhamical or magical compounds. The condition occurs due to intolerance by the nervous system of a chemical or magical substance, or a combination of substances. More commonly, it occurs due to the mixing of magical effects.

Effects

Like more mundane concoctions, magical and alkhamical drugs affect the body and mind. In low amounts, potions are useful in numerous applications -- the most common being analgesia and the promotion of bodily healing. Some magi claim that even in small amounts, mild potiondaze is observable. Karthani studies have demonstrated impaired judgement and changes in magical finesse after two standard healing potions.

At medium levels of consumption -- more than three standard potions in an hour -- the change to magical finesse becomes more pronounced. A magi's ability to focus the effects of magic becomes clumsy; their magic grows unpredictable, and physiological effects of potiondaze begin to appear. These effects vary greatly with the potions consumed, but can be divided into physical effects, which affect all persons with potiondaze, and alkhamical effects, which affect persons with potiondaze who can use magic.

Levels of Severity

Severity

Physical

Alkhamical

Mild

Lowered heart rate, mild confusion, impaired motor skills.

Mildly impaired magical control.

Moderate

Impaired reasoning, confusion, dizziness, ataxia, nausea and vomiting, anterograde amnesia.

Magic misfires and displays odd shifts in elemental properties. Spontaneous magic may occur.

Severe

Seizures, unconsciousness, stupor, loss of understanding, low possibility of death.

Spontaneous magic is likely to occur, possibility of loss of magical ability.

Treatment & Prognosis

The body detoxifies the blood of potion substances over a period of time that depends on the initial level and overall condition. People who have consumed potions heavily for several days or weeks may experience withdrawal symptoms after the acute symptoms have subsided. A person consuming dangerous amounts of potions persistently can develop memory blackouts, resistance to potions and magical effects, and permanent loss of magical ability.

Cultural Perspectives

Due to the controlled production of potions and alchemy, potiondaze is exceedingly rare outside Kartharni and Alkhafi lands. However, Cetoilais physicians and healers have diagnosed a small number of people with the condition. Potiondaze is unknown in many lands due to the formerly mentioned regulation and the overlap this condition's symptoms have with more mundane forms of intoxication. The fuzzy definition of alkhamy has led some people to colloquially call alcohol intoxication potiondaze, either as humour or honest mistake.

Karthani society views the suffering of potiondaze as evidence of weakness of character. A person may experience some few times in their life as they discover their tolerance for potions, or when a situation calls for recklessness, but multiple episodes suggest impulsivity, a lack of intrapersonal knowledge and a dangerous lack of restraint.