Transhumans

"So, what's the deal with her?" he asked the bigger boy.

"What do you mean?... Oh."

"Yeah, that. She's no alien -- there's no such thing as aliens -- but she can't be human either... can she?"

"Think about it. She's a hacker. And nowadays we can tweak genes or perform surgery from within with nanobots."

"So... she hacked her own body? But why? The whole reason we're on another planet at all is that Homo Sapiens is flexible."

"Indeed. Jacks of all trades, masters of none. Sometimes that's more constraining than liberating."

— Parole Planet

Envied by some, feared by others, transhumans -- or "the augmented", as they are known in various cultures -- have been in turn outcasts, saviors, rulers, and outcasts again. Then humanity took to the stars, and things became really complicated.
It's still traditional on the far side of the galaxy for spacers to augment themselves, while ground-bound people tend to remain baseline, and there's a rivalry between the two groups. In more civilized parts, where space travel is safer, people mix up more... and that leads to more varied social dynamics. Not always in a good sense, either.
As for what transhumans actually are, there have been all sorts of experiments and hybrids over the centuries, but in time a few categories have become typical.

Genetic Descendants

• Cyborgs
• Genemorphs
• Sorcerers
• Vampires

Are medical / cyborg / vampire nanobots affected by EMPs?

No more than the human body itself. Nanobots designed to work inside the body are basically just smarter white cells, made from organic materials. They can also self-replicate to a degree to cover losses.

Are there hybrid, exotic or other types of transhumans?

Sure. Genemorphs can become cyborgs or vampires, and there are other ways to improve on baseline humans. Rumor has it that on the far side of the galaxy people are even moving into the realm of the posthuman by now.

Can transhumans other than genemorphs have children?

Yes, of course. Cyborgs and vampires are genetically human, and their nanobots stick to the bloodstream, so they're fine. Sorcerers however would endanger their own partners and children if they tried, as every cell of their bodies contains magic.